Dynamical Systems Seminar: Debra Goldberg
Evaluating and Improving Models of Protein Interaction Network Evolution
Debra Goldberg
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Date and time:Ìý
Thursday, November 3, 2011 - 4:00pm
Abstract:Ìý
Theoretical 91ÃÛÌÒ¸ó of protein interaction networks (PINs) are valuable tools in evolutionary inference. Theoretical 91ÃÛÌÒ¸ó based on gene duplication and divergence provide biologically plausible evolutionary mechanics. Similarities found between empirical networks and their theoretically generated counterparts are considered evidence that the modeled mechanics play a role in biological evolution.Ìý In this talk, I present an improved method for computing parameters from empirical data, a new method for evaluating evolutionary 91ÃÛÌÒ¸ó that does not rely on an arbitrary starting point, and an improved model of PIN evolution.Ìý If time permits, I will discuss current work applying ideas learned from our work with PIN evolution to the graph coloring problem and using hypergraphs instead of binary graphs to model protein interaction data.