Multivariate Concepts
Overview
- Originally presented: June 9, 2026
- Lead: Andrew Grotzinger
- Topics: genetic correlations, LD-score regression, Genomic SEM
This lecture series focuses on advanced methods in genome-wide association studies (GWAS) and statistical genetics, with an emphasis on analyzing and modeling complex traits using summary-level genomic data. Students are introduced to practical workflows for preparing and formatting GWAS data, including quality control steps and tools such as munging functions. The series then explores key analytical techniques like linkage disequilibrium score regression (LDSC), multivariate GWAS, and GWAS-by-subtraction, highlighting how genetic relationships between traits can be estimated. It also introduces structural equation modeling (SEM) and its application in Genomic SEM to model the shared genetic architecture of multiple traits.
Lectures
This series of lectures can be viewed as a .
Genomic SEM Introduction
Lavaan syntax and SEM introduction
Explaining how S and V are estimated and what they are
The munge function
Estimating LDSC
Running usermodel
Formatting GWAS data using sumstats
Estimating multivariate GWAS with userGWAS
GWAS-by-subtraction
Ìý
Practicals
The practical uses these slides, and this .
- Online Lectures and Practicals
- 2026 International Statistical Genetics Workshop
- Syllabus
- Day 0, Before the start of the course
- Day 1, June 1, Background
- Day 2, June 2, Working with data
- Day 3, June 3, Modeling genetic and environmental components
- Day 4, June 4, LMM GWAS
- Day 5, June 8, Prediction
- Day 6, June 9, Multivariate Concepts
- Day 7, June 10, Mendelian randomization
- Day 8, June 11, Biological Interpretation
- Syllabus
- 2025 International Statistical Genetics Workshop
- ISG International Scholar and Cultural Exchange Program
- Guidelines for positive, inclusive, and responsible conduct
- 2024 International Statistical Genetics Workshop
- 2023 International Statistical Genetics Workshop
- 2022 International Statistical Genetics Workshop
- 2021 International Statistical Genetics Workshop
- 2020 International Statistical Genetics Workshop
- 2019 International Statistical Genetics Workshop
- 2027 International Statistical Genetics Workshop
- ISGW early registration program for people requiring a visa